word

Regulatory T Cell (Treg)

REG-yoo-lah-tor-ee TEE SEL

/ˈrɛɡjʊlətɔːri tiː sɛl/

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Syllable breakdown

regulatoryTcell

Dictionary meaning

A specialised subpopulation of CD4+ T cells (characteristically expressing FOXP3) that suppresses immune responses to maintain self-tolerance and prevent autoimmunity; Tregs act via IL-10, TGF-β secretion, cytotoxicity, and competition for growth factors.

Examples

Depletion of Tregs in tumour microenvironments can enhance anti-cancer immune responses.

Synonyms: suppressor T cell, Treg

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