word
T Cell Receptor Signaling
TEE SEL reh-SEP-ter SIG-nul-ing
/tiː sɛl rɪˈsɛptər ˈsɪɡnəlɪŋ/Listen
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Syllable breakdown
Tcellreceptorsignaling
Dictionary meaning
The cascade of intracellular events triggered when the T cell receptor (TCR) binds to a peptide-MHC complex on an antigen-presenting cell, initiating T cell activation, proliferation, and effector function via kinase cascades (e.g., ZAP-70, LAT, PLC-γ) and transcription factor activation (NFAT, NF-κB, AP-1).
Examples
- Defects in TCR signaling can lead to immunodeficiency or autoimmunity depending on which component is affected.
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