word
Protein–Protein Interaction
PROH-teen PROH-teen in-ter-AK-shun
/ˈproʊtiːn ˈproʊtiːn ˌɪntərˈækʃən/Listen
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Syllable breakdown
ProteinProteinInteraction
Dictionary meaning
The physical contact established between two or more protein molecules as a result of biochemical events and/or electrostatic forces. Protein–protein interactions underlie virtually all biological processes, including signal transduction, immune response, and gene regulation. Mapping these interaction networks (the interactome) is a major goal of systems biology.
Examples
- Disrupting the protein–protein interaction between p53 and MDM2 is a therapeutic strategy in cancer.
- High-throughput yeast two-hybrid screens are used to map protein–protein interactions on a proteome-wide scale.
Synonyms: PPI, protein interaction
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