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Protein Folding

PROH-teen FOHL-ding

/ˈproʊtiːn ˈfoʊldɪŋ/

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Syllable breakdown

ProteinFolding

Dictionary meaning

The physical process by which a polypeptide chain acquires its functional three-dimensional structure. The amino acid sequence dictates the final folded conformation, and misfolding is associated with diseases such as Alzheimer's, Parkinson's, and prion diseases. AlphaFold, a deep-learning system by DeepMind, revolutionized the computational prediction of protein structures.

Examples

  • Protein folding is one of the most complex problems in structural biology.
  • The AlphaFold database has provided predicted protein folding data for nearly every known protein.

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