word
Post-Translational Modification
pohst-trans-LAY-shun-ul mod-ih-fih-KAY-shun
/poʊst trænsˈleɪʃənəl ˌmɒdɪfɪˈkeɪʃən/Listen
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Syllable breakdown
PostTranslationalModification
Dictionary meaning
The chemical modification of a protein after it has been synthesized by ribosomes. Common post-translational modifications include phosphorylation, glycosylation, ubiquitination, and acetylation. These changes can activate or inactivate proteins, target them to specific cellular locations, or mark them for degradation.
Examples
- Phosphorylation is one of the most common post-translational modifications and is central to cell signaling.
- The study catalogued over 400 distinct post-translational modifications on histone proteins.
Synonyms: PTM
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