word
MHC Class I and II
em-aych-SEE KLAS WUN and TOO
/ɛm eɪtʃ siː klɑːs wʌn ænd tuː/Listen
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Syllable breakdown
MHCclassIandII
Dictionary meaning
Major histocompatibility complex molecules encoded in the human leukocyte antigen (HLA) region: Class I molecules are expressed on nearly all nucleated cells and present intracellular peptides to CD8+ cytotoxic T cells; Class II molecules are expressed on professional antigen-presenting cells and present extracellular peptides to CD4+ helper T cells.
Examples
- Organ transplant rejection is largely driven by mismatches between donor and recipient MHC class I and II alleles.
Synonyms: HLA molecule, human leukocyte antigen
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