word
cytokine storm
SY-toh-kyn STORM
ˈsaɪtəkaɪn stɔːrmListen
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Syllable breakdown
cytokinestorm
Dictionary meaning
a life-threatening systemic inflammatory response caused by the sudden and massive release of cytokines — small signalling proteins that coordinate immune responses — resulting in a self-amplifying cascade of immune activation that causes widespread tissue damage; observed in severe infections including influenza and COVID-19, in CAR-T cell therapy, and in certain autoimmune conditions; management focuses on cytokine blockade using agents such as tocilizumab
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