word
Cytokine Storm
SY-toh-kyn STORM
/ˈsaɪtəkaɪn stɔːrm/Listen
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Syllable breakdown
cytokinestorm
Dictionary meaning
A life-threatening systemic inflammatory response characterised by the uncontrolled overproduction of pro-inflammatory cytokines (such as IL-6, TNF-α, IFN-γ), leading to multi-organ damage; observed in severe infections (e.g., influenza, COVID-19), sepsis, and following CAR-T cell therapy.
Examples
- Clinicians managing cytokine storm in severe COVID-19 cases used IL-6 receptor blockers to reduce inflammation.
Synonyms: hypercytokinemia, cytokine release syndrome
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