word
Checkpoint Inhibitor
CHEK-point in-HIB-ih-ter
/ˈtʃɛkpɔɪnt ɪnˈhɪbɪtər/Listen
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Syllable breakdown
checkpointinhibitor
Dictionary meaning
A class of immunotherapy drugs that block inhibitory immune checkpoint proteins (such as PD-1, PD-L1, or CTLA-4), thereby releasing brakes on the immune system and allowing T cells to mount a stronger anti-tumour response.
Examples
- Checkpoint inhibitors like pembrolizumab have transformed the treatment of advanced melanoma.
Synonyms: immune checkpoint inhibitor, ICI
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