CAR-T cell therapy

Syllable breakdown

Dictionary meaning

a form of immunotherapy in which a patient's own T lymphocytes are extracted, genetically engineered to express chimeric antigen receptors (CARs) that direct them to recognise and attack cancer cells, then infused back into the patient; has shown remarkable results in certain blood cancers including B-cell acute lymphoblastic leukaemia; side effects can include cytokine release syndrome and neurotoxicity, and manufacturing complexity limits availability