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B Cell Maturation

BEE SEL mach-ur-AY-shun

/biː sɛl ˌmætʃəˈreɪʃən/

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Syllable breakdown

Bcellmaturation

Dictionary meaning

The developmental process by which B lymphocytes progress from bone marrow progenitors through pro-B, pre-B, immature B, and transitional stages to mature naive B cells, undergoing V(D)J recombination and negative selection to generate a diverse, self-tolerant antibody repertoire.

Examples

  • B cell maturation in the bone marrow eliminates autoreactive clones through receptor editing or clonal deletion.

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