word
Allosteric Regulation
al-oh-STEER-ik reg-yoo-LAY-shun
/ˌæloʊˈstɛrɪk ˌrɛɡjʊˈleɪʃən/Listen
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Syllable breakdown
AllostericRegulation
Dictionary meaning
A mechanism by which the binding of a molecule (effector) to a site other than the active site (the allosteric site) of an enzyme causes a conformational change that alters the enzyme's activity. Allosteric regulation is a critical form of cellular feedback control, allowing cells to rapidly modulate metabolic pathway rates.
Examples
- ATP inhibits phosphofructokinase through allosteric regulation, slowing glycolysis when energy is abundant.
- Drug designers increasingly target allosteric sites as an alternative to blocking active sites directly.
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